The effects of theta-burst stimulation on vigilance in humans

• Main Authors: Armand eMensen, Corina eGorban, Marcel eNiklaus, Eva eKuske, Ramin eKhatami
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2014-06-01
• Series: Frontiers in Human Neuroscience
• Subjects: Sleep; Transcranial Magnetic Stimulation; pre-frontal cortex; vigilance; theta-burst stimulation; Associative visual cortex
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00420/full

Repetitive transcranial magnetic stimulation has become a popular tool to modulate neuronal networks and associated brain functions in both clinical and basic research. Yet few studies have examined the potential effects of cortical stimulation on general levels of vigilance. In this exploratory study, we used theta-burst protocols, both continuous (cTBS) and intermittent (iTBS) patterns, to examine whether inhibition or excitation of the left dorso-lateral prefrontal cortex (dlPFC) was able to induce reliable and acute changes to vigilance measures, compared to the left dorso-lateral associative visual cortex (dlAVC) as a control site in line with previous work. Partially sleep restricted participants underwent four separate sessions in a single day, in a between subjects design for TBS stimulation type and within subjects for locaton, each consisting of maintenance of wakefulness test, a sleep latency test, and a psychomotor vigilance task. TBS significantly affected measures of sleep consolidation, namely latency to sleep stage 2 and sleep efficiency, but had no effects on sleep drive or psychomotor vigilance levels for either TBS type or location. Contrary to our initial hypothesis of the dlAVC as a control site, stimulation to this region resulted in the largest differential effects between stimulation types. Moreover, the effect of TBS was found to be consistent throughout the day. These data may provide the basis for further investigation into therapeutic applications of TBS in sleep disorders.