| Summary: | Christelle Chemaga Nkonpawa,1 Vicky Jocelyne Ama Moor,1,2 Aurel T Tankeu,3 Audrey Synthia Momo,1 Guy Sadeu Wafeu,4 Falmata Amazia,2 Jan Rene Nkeck,2,5 Tasha Manases,6 Julius Dohbit Sama,7 Simeon Pierre Choukem6,8,9 1Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; 2Laboratory of Biochemistry, University Teaching Hospital, Yaoundé, Cameroon; 3Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; 4Centre for Research on Filariasis and Other Tropical Diseases, Yaoundé, Cameroon; 5Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; 6Health and Human Development Research Network, Douala, Cameroon; 7Department of Obstetrics and Gynecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; 8Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon; 9Department of Internal Medicine and Specialties, Douala General Hospital, Douala, CameroonCorrespondence: Aurel T Tankeu Route d’Oron 77, Lausanne, 1010, SwitzerlandTel +4176 772 3001Email aurelnet2014@yahoo.comBackground: Studies report high levels of inflammatory markers in women with polycystic ovary syndrome (PCOS), reflecting chronic low-grade inflammation. This inflammation is thought to be associated with insulin resistance. We aim to evaluate inflammatory markers [high sensitivity C reactive protein (CRP) and interleukin 6] and insulin resistance in women with PCOS in Yaoundé, Cameroon.Methods: We conducted a comparative cross-sectional study including 32 women with PCOS aged between 18 and 44 years and 32 controls matched for age and body mass index (BMI). Homeostasis model assessment of insulin resistance (HOMA-IR) index calculated using C peptide levels was used to evaluate insulin resistance. Serum levels of high sensitivity CRP (hsCRP) and interleukin 6 (IL-6) were measured. Comparisons were made using the Student’s T-test and non-parametric tests (Mann–Whitney U-test, Kruskal–Wallis test).Results: We found that the median [25th– 75th percentile] level of hsCRP was significantly higher in women with PCOS compared to the controls (0.63 [0.32– 3.81] mg/L vs. 0.47 [0.15– 1.04] mg/L; p=0.01), while IL-6 levels were not different (8.61 [4.1– 33.79] pg/mL for PCOS vs. 8.80 [5.28– 38.85] pg/mL for controls; p=0.51). We noted that women with PCOS had a higher HOMA-IR index (1.15± 0.90 vs. 0.77± 0.38; p=0.03). However, there was no correlation between hsCRP level and the HOMA-IR index (Spearman correlation coefficient=0.10; p=0.62).Conclusion: PCOS is associated with an increased level of hsCRP and insulin resistance in Cameroonian women. This exploratory study provides baseline evidence for larger-scale studies.Keywords: interleukin 6, high sensitivity C reactive protein, polycystic ovary syndrome, insulin resistance, sub-Saharan Africa
|
|---|
