Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

• Main Authors: Liu F, Wang Y, Zhao Q, Zhang M, Ban B
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-07-01
• Series: International Journal of General Medicine
• Subjects: uric acid; insulin-like growth factor-1; type 2 diabetes mellitus
• Online Access: https://www.dovepress.com/association-between-uric-acid-and-insulin-like-growth-factor-1-in-type-peer-reviewed-fulltext-article-IJGM

Fang Liu,1 Yaru Wang,1 Qiang Zhao,2 Mei Zhang,3,4 Bo Ban3,4 1Department of Clinical Medicine, Jining Medical University, Jining, Shandong, 272067, People’s Republic of China; 2Department of Clinical Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272029, People’s Republic of China; 4Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong, 272029, People’s Republic of ChinaCorrespondence: Bo BanDepartment of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, Shandong, 272029, People’s Republic of ChinaEmail [e-mail]: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM).Methods: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS).Results: The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (P< 0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was < 4.17 mg/dl (β 0.12,95% CI − 0.04, 0.28; P=0.121) and decreased when UA was > 4.17 mg/dl (β − 0.38,95% CI − 0.64, − 0.12; P=0.004).Conclusion: This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.Keywords: uric acid, insulin-like growth factor-1, type 2 diabetes mellitus