| Summary: | The major aim of this work was to understand and estimate the evolution of the membrane selectivity of neutral solutes after the filtration of protein or amino acid solutions. Classical methodologies led to the estimation of the mean pore radius, different for each filtrated neutral solute. The use of pore size distribution from nitrogen adsorption/desorption experiments enabled a good description of hydraulic and selectivity performances. The modification of the membrane hydraulic properties after the successive filtration of protein solutions revealed that the decrease is quasi linear, the same for all the studied membranes and independent of prior tests. According to the experimental observations, an adsorption model was developed, considering a layer by layer adsorption in the larger pores of the membrane. The predictive obtained results are in good agreement with the experimental rejection rates, validating the assumptions.
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