Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development

The serine/threonine protein phosphatase 2A (PP2A) is a master regulator of the complex cellular signaling that occurs during all stages of mammalian development. PP2A is composed of a catalytic, a structural, and regulatory subunit, for which there are multiple isoforms. The association of specific...

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Bibliographic Details
Main Authors: Nikita Panicker, Melody Coutman, Charley Lawlor-O’Neill, Richard G. S. Kahl, Séverine Roselli, Nicole M. Verrills
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PP2A
knockout mouse
embryo
lethality
skin
epidermal barrier
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00358/full

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