Stereoselective bioreduction of someMannich bases

• Main Authors: Bruna S. D. R. Aranha, Nelson L.C. Domingues, Andrelson W. Rinaldi
• Format: Article
• Language: English
• Published: Universidade Federal de Mato Grosso do Sul 2012-06-01
• Series: Orbital: The Electronic Journal of Chemistry
• Subjects: chymosin; mannich reactions; bioreduction
• Online Access: http://orbital.ufms.br/index.php/Chemistry/article/view/340

<em>The chemic reaction that happen on the live organism (plants, superior animals and microorganisms) produce various chiral substances such as pheromones, antibiotics and others. After the eighties, with the break of the dogma referent to the enzymatic utilization only in aqueous medias, diverse enzyme application were revealed in other reaction medias, what allowed new studies turned to enzymatic application in organic chemistry. Such studies revealed that these biocatalysts presented high selectivity in these medias, no only about to the chemoselectivity but especially to the enantioselectivity. According to what was exposed, this work aimed to execute the bioreduction of some Mannich bases using the microorganism Saccharomyces cerevisiae (sourdough bread). Scheme 1 shows the reaction scheme involving 1 eq.mol of the b-aminocarbonilated product, 10 mL of   the suitable solvent and 0,5g of the biocatalys</em><em> during four days at room temperature. These reactions presented satisfactory yields, which are in accordance with the literature.</em><em></em>