Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

<h4>Background</h4>Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC-/- mice) display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromosome instability reduce...

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Bibliographic Details
Main Authors: Rabindra N Bhattacharjee, Birendranath Banerjee, Shizuo Akira, M Prakash Hande
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20686699/?tool=EBI

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