| Summary: | <p>Abstract</p> <p>Background</p> <p>The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.</p> <p>Results</p> <p>The extract of <it>Cinnamomum zeylanicum</it> against <it>Escherichia coli</it> ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of <it>Dorstenia psilurus</it> was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine<it>-β-</it> Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY).</p> <p>Conclusion</p> <p>The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.</p>
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