A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.

A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.

Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome of efficacy trials. To address this gap, candidate biomarkers of microbicide pharmacodynamics and safety were evaluated in a double-blind, placebo-controlled trial of tenofovir gel, the first microbi...

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Main Authors: Marla J Keller, Rebecca P Madan, N Merna Torres, Melissa J Fazzari, Sylvia Cho, Sabah Kalyoussef, Gail Shust, Pedro M M Mesquita, Nicolette Louissaint, Jianmeng Chen, Hillel W Cohen, Erin C Diament, Anna C Lee, Lydia Soto-Torres, Craig W Hendrix, Betsy C Herold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3026837?pdf=render

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