SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction

A 26-year-old man with symptomatic SARS-CoV-2 infection developed a sudden-onset acute testicular pain. The echo-doppler images showed massive testicular infarction, so orchiectomy was performed. On gross examination, the surgical specimen showed complete testicular necrosis and diffuse thickening o...

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Main Authors:	Dámaso Parrón, Ane Gartzia, Ane M. Iturregui, Igone Imaz, Claudia Manini, Jorge García-Olaverri, José I. López
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Clinics and Practice
Subjects:	SARS-CoV-2 COVID-19 arteritis pathology testicular infarction
Online Access:	https://www.mdpi.com/2039-7283/11/2/37

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spelling	doaj-078a8942016a4ab0b9d69c9986ec31262021-05-31T23:16:24ZengMDPI AGClinics and Practice2039-72832021-05-01113724624910.3390/clinpract11020037SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular InfarctionDámaso Parrón0Ane Gartzia1Ane M. Iturregui2Igone Imaz3Claudia Manini4Jorge García-Olaverri5José I. López6Department of Pathology, Cruces University Hospital, Barakaldo, 48903 Bizkaia, SpainDepartment of Pathology, Cruces University Hospital, Barakaldo, 48903 Bizkaia, SpainDepartment of Urology, Cruces University Hospital, Barakaldo, 48903 Bizkaia, SpainDepartment of Pathology, Cruces University Hospital, Barakaldo, 48903 Bizkaia, SpainDepartment of Pathology, San Giovanni Bosco Hospital, 10154 Turin, ItalyDepartment of Urology, Cruces University Hospital, Barakaldo, 48903 Bizkaia, SpainDepartment of Pathology, Cruces University Hospital, Barakaldo, 48903 Bizkaia, SpainA 26-year-old man with symptomatic SARS-CoV-2 infection developed a sudden-onset acute testicular pain. The echo-doppler images showed massive testicular infarction, so orchiectomy was performed. On gross examination, the surgical specimen showed complete testicular necrosis and diffuse thickening of the testicular coverings. Under the microscope, a severe obliterative arteritis was evidenced. SARS-CoV-2 spike antibody was detected by immunohistochemistry in the arterial endothelium. Electron microscopy displayed intracytoplasmic spiky viral particles in endothelial cells. The patient was treated with corticoids and was asymptomatic at last contact.https://www.mdpi.com/2039-7283/11/2/37SARS-CoV-2COVID-19arteritispathologytesticular infarction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dámaso Parrón Ane Gartzia Ane M. Iturregui Igone Imaz Claudia Manini Jorge García-Olaverri José I. López
spellingShingle	Dámaso Parrón Ane Gartzia Ane M. Iturregui Igone Imaz Claudia Manini Jorge García-Olaverri José I. López SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction Clinics and Practice SARS-CoV-2 COVID-19 arteritis pathology testicular infarction
author_facet	Dámaso Parrón Ane Gartzia Ane M. Iturregui Igone Imaz Claudia Manini Jorge García-Olaverri José I. López
author_sort	Dámaso Parrón
title	SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction
title_short	SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction
title_full	SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction
title_fullStr	SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction
title_full_unstemmed	SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction
title_sort	sars-cov-2-associated obliterative arteritis causing massive testicular infarction
publisher	MDPI AG
series	Clinics and Practice
issn	2039-7283
publishDate	2021-05-01
description	A 26-year-old man with symptomatic SARS-CoV-2 infection developed a sudden-onset acute testicular pain. The echo-doppler images showed massive testicular infarction, so orchiectomy was performed. On gross examination, the surgical specimen showed complete testicular necrosis and diffuse thickening of the testicular coverings. Under the microscope, a severe obliterative arteritis was evidenced. SARS-CoV-2 spike antibody was detected by immunohistochemistry in the arterial endothelium. Electron microscopy displayed intracytoplasmic spiky viral particles in endothelial cells. The patient was treated with corticoids and was asymptomatic at last contact.
topic	SARS-CoV-2 COVID-19 arteritis pathology testicular infarction
url	https://www.mdpi.com/2039-7283/11/2/37
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SARS-CoV-2-Associated Obliterative Arteritis Causing Massive Testicular Infarction

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