cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells

cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells

Cytosolic phospholipase A2 (cPLA2) is activated by phosphorylation at serine-505 (S505) by extracellular regulated kinase 1/2 (ERK1/2). However, rat brain calcium/calmodulin-dependent kinase II (CaMKII) phosphorylates recombinant cPLA2 at serine-515 (S515) and increases its activity in vitro. We hav...

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Bibliographic Details
Main Authors: Zoran Pavicevic, Christina C. Leslie, Kafait U. Malik
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Journal of Lipid Research
Subjects:
cytosolic phospholipase A2
calcium/calmodulin-dependent kinase II
extracellular regulated kinase 1/2
adenovirus cytosolic phospholipase A2 wild type
mutants S505A and S515A
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520423867

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http://www.sciencedirect.com/science/article/pii/S0022227520423867

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