Somatic mutation patterns and compound response in cancers

• Main Authors: Ningning He, Nayoung Kim, Sukjoon Yoon
• Format: Article
• Language: English
• Published: Korean Society for Biochemistry and Molecular Biology 2013-02-01
• Series: BMB Reports
• Subjects: Cancer mutation; Cell line enrichment analysis; Compound response; GI50; NCI60
• Online Access: http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI2MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0yJTVEMTMwMjI2MTg0NF8lMjgwOTctMTAyJTI5Qk1CXzEyLTIyNi5wZGY=

The use of various cancer cell lines can recapitulate knowntumor-associated mutations and genetically define cancersubsets. This approach also enables comparative surveys ofassociations between cancer mutations and drug responses.Here, we analyzed the effects of ∼40,000 compounds oncancer cell lines that showed diverse mutation-dependentsensitivity profiles. Over 1,000 compounds exhibited uniquesensitivity on cell lines with specific mutational genotypes,and these compounds were clustered into six different classesof mutation-oriented sensitivity. The present analysis providesnew insights into the relationship between somatic mutationsand selectivity response of chemicals, and these results shouldhave applications related to predicting and optimizing therapeuticwindows for anti-cancer agents. [BMB Reports 2013;46(2): 97-102]