THE MOLECULAR MECHANISM OF LACTOFERRIN INFLUENCE ON BONE FORMATION

• Main Authors: P E Sadchikov, I L Goldman, S V Razin, A D Chernousov, L I Alekseeva, E R Sadchikova
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2016-12-01
• Series: Остеопороз и остеопатии
• Online Access: https://endojournals.ru/index.php/osteo/article/view/9201

In present critical review of systematized materials on the breakthrough achievements of the last decade - the discovery of the effect of protein lactoferrin (LF) on bone formation. It is shownthat LF increases the number of osteoblasts, stimulate their proliferation and differentiation, and prevents their destruction. Action of LF exceeds that of many other previously established bone-forming factors. LF increases the ability of osteoblasts to synthesize and mineralize bone matrix. Apparently, the effect of LF on bone anabolism ensured by the presence of specific receptors on osteoblasts. It was found that LF also inhibits the formation of osteoclasts. Experimental studies have demonstrated that LF prevents the destruction of bone tissue in ovariectomizedanimals and, thus, developing the type of postmenstrual osteoporosis in women. We get the first clinical studies demonstrating an increase in the period of healing of bone injuries while reducing the level of endogenous LF. Since molecular research establishes that the expression of the LF gene is regulated by estrogen, which reduces the development of postmenopausal osteoporosis (PMO) in women, there is a need to further investigate the relationship of these processes, which will help to create a basis for the management of bone formation.