Design for a multicenter, randomized, sham-controlled study to evaluate safety and efficacy after treatment with the Nuvaira® lung denervation system in subjects with chronic obstructive pulmonary disease (AIRFLOW-3)

Design for a multicenter, randomized, sham-controlled study to evaluate safety and efficacy after treatment with the Nuvaira® lung denervation system in subjects with chronic obstructive pulmonary disease (AIRFLOW-3)

Abstract Background Targeted lung denervation (TLD) is a bronchoscopically delivered ablation therapy that selectively interrupts pulmonary parasympathetic nerve signaling. The procedure has the potential to alter airway smooth muscle tone and reactivity, decrease mucous secretion, and reduce airway...

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Bibliographic Details
Main Authors: Dirk-Jan Slebos, Bruno Degano, Arschang Valipour, Pallav L. Shah, Gaetan Deslée, Frank C. Sciurba, on behalf of the AIRFLOW-3 Trial Study Group
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Pulmonary Medicine
Subjects:
COPD
Nerves
Targeted lung denervation
Acetylcholine
Anticholinergic
Bronchoscopy
Online Access:https://doi.org/10.1186/s12890-020-1058-5

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