Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism

Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism

Background and Purpose: Post-traumatic cardiac dysfunction often occurs in multiply injured patients (ISS ≥ 16). Next to direct cardiac injury, post-traumatic cardiac dysfunction is mostly induced by the release of inflammatory biomarkers. One of these is the heparin-binding factor Midkine, which is...

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Bibliographic Details
Main Authors: Ina Lackner, Birte Weber, Meike Baur, Melanie Haffner-Luntzer, Tim Eiseler, Giorgio Fois, Florian Gebhard, Borna Relja, Ingo Marzi, Roman Pfeifer, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hans-Christoph Pape, Miriam Kalbitz, TREAT Research Group
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
polytrauma
cardiac dysfunction
fracture treatment
damage associated molecular pattern
toll-like receptor
toll-like receptor signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01920/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01920/full

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