Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept

Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept

Abstract Background Melanocortin receptor (MCR) agonists have anti-inflammatory and immunomodulatory properties mediated by receptors expressed on cells relevant to arthritis. Repository corticotropin injection (RCI; Acthar® Gel), an MCR agonist preparation, is approved as adjunctive therapy for rhe...

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Bibliographic Details
Main Authors: Dima A. Decker, Paul Higgins, Kyle Hayes, Chris Bollinger, Patrice Becker, Dale Wright
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Musculoskeletal Disorders
Subjects:
Rheumatoid arthritis
Melanocortin receptor agonist
Repository corticotropin injection
Bone loss
Etanercept
Osteoclast
Online Access:http://link.springer.com/article/10.1186/s12891-020-03609-3

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