Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)

Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)

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The cardiac cavity of an isolated rat heart was filled with a Krebs-Henseleit (KH) solution, and the heart was hung in a high-pressure chamber. After the high-pressure chamber had been filled with a mixed gas (PCO = 400 hPa, PCO 2 = 100 hPa, PO 2 = 900 hPa, PHe = 5600 hPa) and preserved for 72 h, we...

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Main Authors: Naoyuki Hatayama, Yu Yoshida, Kunihiro Seki
Format: Article
Language:English
Published: SAGE Publishing 2010-06-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368910X508807
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spelling doaj-0766efe2204d4aed9e34056725d119532020-11-25T01:25:47ZengSAGE PublishingCell Transplantation0963-68971555-38922010-06-011910.3727/096368910X508807Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)Naoyuki Hatayama0Yu Yoshida1Kunihiro Seki2Resonance Club Co., Ltd., Tokyo, JapanResonance Club Co., Ltd., Tokyo, JapanResonance Club Co., Ltd., Tokyo, JapanThe cardiac cavity of an isolated rat heart was filled with a Krebs-Henseleit (KH) solution, and the heart was hung in a high-pressure chamber. After the high-pressure chamber had been filled with a mixed gas (PCO = 400 hPa, PCO 2 = 100 hPa, PO 2 = 900 hPa, PHe = 5600 hPa) and preserved for 72 h, we performed a cervical ectopic heart transplantation on a recipient rat and resuscitated the preserved heart. This is the first incidence in the world of a mammalian organ having been successfully preserved and resuscitated after 72 h via a desiccation method.https://doi.org/10.3727/096368910X508807
collection DOAJ
language English
format Article
sources DOAJ
author Naoyuki Hatayama
Yu Yoshida
Kunihiro Seki
spellingShingle Naoyuki Hatayama
Yu Yoshida
Kunihiro Seki
Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)
Cell Transplantation
author_facet Naoyuki Hatayama
Yu Yoshida
Kunihiro Seki
author_sort Naoyuki Hatayama
title Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)
title_short Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)
title_full Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)
title_fullStr Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)
title_full_unstemmed Seventy-Two-Hour Preservation, Resuscitation, and Transplantation of an Isolated Rat Heart with High Partial Pressure Carbon Monoxide Gas (PCO = 400 hPa) and High Partial Pressure Carbon Dioxide (PCO = 100 hPa)
title_sort seventy-two-hour preservation, resuscitation, and transplantation of an isolated rat heart with high partial pressure carbon monoxide gas (pco = 400 hpa) and high partial pressure carbon dioxide (pco = 100 hpa)
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2010-06-01
description The cardiac cavity of an isolated rat heart was filled with a Krebs-Henseleit (KH) solution, and the heart was hung in a high-pressure chamber. After the high-pressure chamber had been filled with a mixed gas (PCO = 400 hPa, PCO 2 = 100 hPa, PO 2 = 900 hPa, PHe = 5600 hPa) and preserved for 72 h, we performed a cervical ectopic heart transplantation on a recipient rat and resuscitated the preserved heart. This is the first incidence in the world of a mammalian organ having been successfully preserved and resuscitated after 72 h via a desiccation method.
url https://doi.org/10.3727/096368910X508807
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AT yuyoshida seventytwohourpreservationresuscitationandtransplantationofanisolatedratheartwithhighpartialpressurecarbonmonoxidegaspco400hpaandhighpartialpressurecarbondioxidepco100hpa
AT kunihiroseki seventytwohourpreservationresuscitationandtransplantationofanisolatedratheartwithhighpartialpressurecarbonmonoxidegaspco400hpaandhighpartialpressurecarbondioxidepco100hpa
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