Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation

Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation

HIV transactivator protein (Tat) plays a pivotal role in viral replication through modulation of cellular transcription factors and transactivation of viral genomic transcription. The effect of HIV-1 Tat on reverse transcription has long been described in the literature, however, that of HIV-2 is un...

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Bibliographic Details
Main Authors: Zsófia Szojka, János András Mótyán, Márió Miczi, Mohamed Mahdi, József Tőzsér
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
human immunodeficiency virus
HIV-2
Tat
stability analysis
reverse transcriptase activity
transactivator protein
Online Access:https://www.mdpi.com/1422-0067/21/16/5907

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