Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α

Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α

<strong>Background:</strong> Multiple myeloma (MM) is a malignant plasma cell proliferative disorder with limited immunotherapy treatment because of T cell dysfunction. <strong>Objective:</strong> To investigate the immunomodulatory function of bone marrow mesenchymal stromal...

Full description

Bibliographic Details
Main Authors:	Yadan Wang, Xiaofei Wu, Yu Hu
Format:	Article
Language:	English
Published:	Shiraz University of Medical Sciences 2019-12-01
Series:	Iranian Journal of Immunology
Subjects:	bone marrow mesenchymal stromal cells cd8+ t cell anergy fibroblast activation protein a multiple myeloma
Online Access:	http://iji.sums.ac.ir/article_45970_dca2395c0cc0b5d6203e03f31c5901a9.pdf

Similar Items

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression
by: Patricia Maiso, et al.
Published: (2021-05-01)

Epigenetic Classification of Human Mesenchymal Stromal Cells
by: Danilo Candido de Almeida, et al.
Published: (2016-02-01)

Stromal Cells Serve Drug Resistance for Multiple Myeloma via Mitochondrial Transfer: A Study on Primary Myeloma and Stromal Cells
by: Zsolt Matula, et al.
Published: (2021-07-01)

Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
by: Anastasia Gabrielyan, et al.
Published: (2017-09-01)

Comparison of endometrial regenerative cells and bone marrow stromal cells
by: Wang Huan, et al.
Published: (2012-10-01)

The Metastatic Bone Marrow Niche in Neuroblastoma: Altered Phenotype and Function of Mesenchymal Stromal Cells
by: Caroline Hochheuser, et al.
Published: (2020-11-01)

Imprinting of Mesenchymal Stromal Cell Transcriptome Persists even after Treatment in Patients with Multiple Myeloma
by: Léa Lemaitre, et al.
Published: (2020-05-01)

Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo
by: Kimberley C. Clark, et al.
Published: (2020-08-01)

Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates
by: Angela W. Xie, et al.
Published: (2021-08-01)

Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles
by: Greet Merckx, et al.
Published: (2020-01-01)

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor
by: Abdelilah Mekhloufi, et al.
Published: (2020-02-01)

MULTIPOTENT MESENCHYMAL STROMAL CELLS OF BONE MARROW IN THERAPY OF CHRONIC INFLAMMATION OF THE MURINE OVARIES
by: Volkova N. А., et al.
Published: (2014-10-01)

Percutaneous Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Implantation Is Safe for Reconstruction of Human Lower Limb Long Bone Atrophic Nonunion
by: Mohsen Emadedin, et al.
Published: (2017-01-01)

Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes
by: Heather Fairfield, et al.
Published: (2021-02-01)

Intrinsic Angiogenic Potential and Migration Capacity of Human Mesenchymal Stromal Cells Derived from Menstrual Blood and Bone Marrow
by: Rosana de Almeida Santos, et al.
Published: (2020-12-01)

Current Understanding of Myelomatous Mesenchymal Stromal Cells Extended through Advances in Experimental Methods
by: Michiko Ichii, et al.
Published: (2021-12-01)

Bone Marrow Stromal Cells-Induced Drug Resistance in Multiple Myeloma
by: Roberto Ria, et al.
Published: (2020-01-01)

Human Mesenchymal Stromal Cell-Derived Exosomes Promote In Vitro Wound Healing by Modulating the Biological Properties of Skin Keratinocytes and Fibroblasts and Stimulating Angiogenesis
by: Raluca Tutuianu, et al.
Published: (2021-06-01)

Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia
by: Kevin Woods, et al.
Published: (2021-08-01)

pIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo
by: Paola Cafforio, et al.
Published: (2017-09-01)

Bone Marrow Multipotent Mesenchymal Stromal Cells as Autologous Therapy for Osteonecrosis: Effects of Age and Underlying Causes
by: Jehan J El-Jawhari, et al.
Published: (2021-05-01)

Microvascular Networks From Endothelial Cells and Mesenchymal Stromal Cells From Adipose Tissue and Bone Marrow: A Comparison
by: Karoline Pill, et al.
Published: (2018-10-01)

Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells
by: Aya Fujishiro, et al.
Published: (2017-09-01)

Arrhythmogenic Cardiomyopathy Is a Multicellular Disease Affecting Cardiac and Bone Marrow Mesenchymal Stromal Cells
by: Arianna Scalco, et al.
Published: (2021-04-01)

Bone Marrow Concentrate Mesenchymal Stromal Cells Do not Correlate With Nucleated Cell Count or Colony Forming Units
by: Marta Cercone, et al.
Published: (2021-09-01)

Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics
by: Féaron C. Cassidy, et al.
Published: (2020-04-01)

TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2−/−-Driven Myeloid Malignancy Progression
by: Rong Li, et al.
Published: (2018-01-01)

Comparison of mesenchymal stem cell surface markers from bone marrow aspirates and adipose stromal vascular fraction sites
by: Meghan eSullivan, et al.
Published: (2016-01-01)

Aging of Bone Marrow Mesenchymal Stromal Cells: Hematopoiesis Disturbances and Potential Role in the Development of Hematologic Cancers
by: Fulvio Massaro, et al.
Published: (2021-12-01)

Comparing the immunomodulatory properties of bone marrow, adipose tissue and birth-associated tissue mesenchymal stromal cells
by: Philipp eMattar, et al.
Published: (2015-11-01)

Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring
by: Cecelia C. Yates, et al.
Published: (2017-09-01)

Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients
by: Atieh Makhlough, et al.
Published: (2017-05-01)

Multipotent mesenchymal stromal cells are sensitive to thermic stress – potential implications for therapeutic hyperthermia
by: Alexander Rühle, et al.
Published: (2020-01-01)

The Role of Amino Acids in the Crosstalk Between Mesenchymal Stromal Cells and Neoplastic Cells in the Hematopoietic Niche
by: Martina Chiu, et al.
Published: (2021-06-01)

Mast Cell-activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34+ Progenitor cells
by: Zoulfia eAllakhverdi, et al.
Published: (2013-12-01)

Bone marrow-derived from the human femoral shaft as a new source of mesenchymal stem/stromal cells: an alternative cell material for banking and clinical transplantation
by: Katarzyna Drela, et al.
Published: (2020-06-01)

Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: Influence of microenvironment, tissue origin and growth factor
by: N Shintani, et al.
Published: (2011-11-01)

The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid Leukemia
by: Marilena Ciciarello, et al.
Published: (2019-10-01)

Low Oxygen Tension Maintains Multipotency, Whereas Normoxia Increases Differentiation of Mouse Bone Marrow Stromal Cells
by: Marco Giorgio, et al.
Published: (2013-01-01)

Which stem cells to choose for regenerative medicine application: Bone marrow and adipose tissue stromal stem cells – Similarities and differences
by: Nehad M Alajez, et al.
Published: (2018-01-01)