Recent updates on CAR T clinical trials for multiple myeloma

• Main Authors: Quande Lin, Juanjuan Zhao, Yongping Song, Delong Liu
• Format: Article
• Language: English
• Published: BMC 2019-11-01
• Series: Molecular Cancer
• Subjects: B cell maturation antigen; BCMA; Chimeric antigen receptor; CAR T; Multiple myeloma
• Online Access: http://link.springer.com/article/10.1186/s12943-019-1092-1
• ISSN: 1476-4598

Abstract Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies have dramatically changed the natural history of multiple myeloma (MM). However, most patients eventually suffer a relapse and succumb to the disease. Chimeric antigen receptor (CAR) engineered T cells targeting B cell maturation antigen (BCMA), CD138, CS1 glycoprotein antigen (SLAMF7) and light chains are in active development for therapy of refractory /relapsed (RR) MM. CD19- targeted CAR T cells in conjunction with autologous stem cell transplantation also showed activity in RRMM. Dual- target CAR T cells are in clinical trials for RRMM. This review summarized the recent updates of ongoing CAR T clinical trials for multiple myeloma.