Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria.

Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria.

Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice leads to experimental cerebral malaria (ECM) that is commonly associated with serious T cell mediated damage. In other parasitic infection models, inflammatory monocytes have been shown to regulate Th1 responses but their role in ECM remains po...

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Bibliographic Details
Main Authors: Beatrix Schumak, Katrin Klocke, Janina M Kuepper, Aindrila Biswas, Andrea Djie-Maletz, Andreas Limmer, Nico van Rooijen, Matthias Mack, Achim Hoerauf, Ildiko Rita Dunay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4401438?pdf=render

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http://europepmc.org/articles/PMC4401438?pdf=render

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