Network pharmacological study on the mechanism of shenfu decoction in the treatment of cardiotoxicity by doxorubicin
Objective: Doxorubicin is an efficient anthracycline drug for the treatment of tumor, however, its cardiotoxicity restricts the clinical application. Shenfu decoction has good clinical effect, but the pharmacological mechanism is not fully clarified. Method: The active components and potential ta...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2020-12-01
|
| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/202023/07.pdf |
| Summary: | Objective: Doxorubicin is an efficient anthracycline drug for the treatment of tumor, however,
its cardiotoxicity restricts the clinical application. Shenfu decoction has good clinical effect,
but the pharmacological mechanism is not fully clarified. Method: The active components
and potential targets of shenfu decoction were screened by TCMSP database, disease targets
of doxorubicin-induced cardiotoxicity were collected by Genecards and OMIM database,
and the network diagram of "drug-components-target-disease" was constructed by Cytoscape
software. PPI network was constructed by STRING database. The target of action of the drug
and the disease gene were mapped for GO and KEGG signal pathway analysis. Results: The
study found that there are 52 main effective components of shenfu decoction, and 76 genes
are involved in the potential therapeutic targets, among which 24 genes are potential targets
of shenfu decoction in the treatment of doxorubicin-induced cardiotoxicity. The protein
interaction network suggested that BCL2、BAX、CASP9、CASP3、MAPK8 may be the
core target. GO enrichment analysis showed 52 cellular biological processes, and enrichment
analysis of KEGG pathway revealed 99 involved signaling pathways, including TNF, apoptosis
signaling pathways , etc. Conclusion: In this study, the network of " drug-components-targetdisease
" was constructed through network pharmacology, and it was found that the mechanism
of " shenfu decoction" in the treatment of doxorubicin-induced cardiotoxicity involves multiple
targets and pathways, which is conducive to guiding clinical medication. |
|---|---|
| ISSN: | 1007-1237 1007-1237 |