HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.

HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.

BACKGROUND: Leishmania is the etiologic agent of leishmanisais, a protozoan disease whose pathogenic events are not well understood. Current therapy is suboptimal due to toxicity of the available therapeutic agents and the emergence of drug resistance. Compounding these problems is the increase in t...

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Main Authors: Lívia O Santos, Fernanda A Marinho, Ellen F Altoé, Bianca S Vitório, Carlos R Alves, Constança Britto, Maria Cristina M Motta, Marta H Branquinha, André L S Santos, Claudia M d'Avila-Levy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2656615?pdf=render

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http://europepmc.org/articles/PMC2656615?pdf=render

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