A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties

A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties

Fate decision processes of T lymphocytes are crucial for health and disease. Whether a T lymphocyte is activated, divides, gets anergic or initiates apoptosis depends on extracellular triggers and intracellular signalling. Free cytosolic calcium dynamics plays an important role in this context. The...

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Bibliographic Details
Main Authors: Christine Dorothee Schmeitz, Esteban Abelardo Hernandez-Vargas, Ralf eFliegert, Andreas H Guse, Michael eMeyer-Hermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
Endoplasmic Reticulum
T lymphocytes
mathematical model
calcium dynamics
CRAC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00277/full

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