Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase

Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase

Threonine is a biosynthetic precursor to dimethylpyrazine derivatives, but the pathway by which this occurs is not fully established. Here l-throenine-3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase together are shown to convert l-threonine to dimethylpyrazine derivatives as a byproduct of gly...

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Main Authors: Tomoharu Motoyama, Shogo Nakano, Fumihito Hasebe, Ryo Miyata, Shigenori Kumazawa, Noriyuki Miyoshi, Sohei Ito
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-021-00545-8
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spelling doaj-0721bf5355e34425a7e030a15af7c97f2021-07-18T11:05:55ZengNature Publishing GroupCommunications Chemistry2399-36692021-07-014111010.1038/s42004-021-00545-8Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolaseTomoharu Motoyama0Shogo Nakano1Fumihito Hasebe2Ryo Miyata3Shigenori Kumazawa4Noriyuki Miyoshi5Sohei Ito6Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of ShizuokaThreonine is a biosynthetic precursor to dimethylpyrazine derivatives, but the pathway by which this occurs is not fully established. Here l-throenine-3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase together are shown to convert l-threonine to dimethylpyrazine derivatives as a byproduct of glycine metabolism.https://doi.org/10.1038/s42004-021-00545-8
collection DOAJ
language English
format Article
sources DOAJ
author Tomoharu Motoyama
Shogo Nakano
Fumihito Hasebe
Ryo Miyata
Shigenori Kumazawa
Noriyuki Miyoshi
Sohei Ito
spellingShingle Tomoharu Motoyama
Shogo Nakano
Fumihito Hasebe
Ryo Miyata
Shigenori Kumazawa
Noriyuki Miyoshi
Sohei Ito
Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
Communications Chemistry
author_facet Tomoharu Motoyama
Shogo Nakano
Fumihito Hasebe
Ryo Miyata
Shigenori Kumazawa
Noriyuki Miyoshi
Sohei Ito
author_sort Tomoharu Motoyama
title Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_short Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_full Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_fullStr Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_full_unstemmed Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_sort chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by l-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate coa ligase/l-threonine aldolase
publisher Nature Publishing Group
series Communications Chemistry
issn 2399-3669
publishDate 2021-07-01
description Threonine is a biosynthetic precursor to dimethylpyrazine derivatives, but the pathway by which this occurs is not fully established. Here l-throenine-3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase together are shown to convert l-threonine to dimethylpyrazine derivatives as a byproduct of glycine metabolism.
url https://doi.org/10.1038/s42004-021-00545-8
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