CEMIP promotes ovarian cancer development and progression via the PI3K/AKT signaling pathway

• Main Authors: Fan Shen, Zhi-hong Zong, Yao Liu, Shuo Chen, Xiu-jie Sheng, Yang Zhao
• Format: Article
• Language: English
• Published: Elsevier 2019-06-01
• Series: Biomedicine & Pharmacotherapy
• Subjects: CEMIP; Ovarian cancer; Tumorigenesis; Metastasis; PI3K/AKT signaling
• Online Access: http://www.sciencedirect.com/science/article/pii/S0753332218380922

CEMIP is a cell migration-inducing protein that is closely associated with carcinogenesis. However, the function of CEMIP has not been reported in ovarian cancer. Here we show that CEMIP expression level in ovarian cancer tissues was higher than that in normal ovaries. Silencing of CEMIP in ovarian cancer cell lines A2780 and OVCAR3 significantly decreased cell proliferation, cell migration and invasion capacity, while the proportion of apoptotic cells was increased. In addition, Western blotting demonstrated that knockdown of CEMIP inhibited activation of the PI3K/AKT signaling pathway. Altogether, these data suggest that CEMIP may promote the development of ovarian cancer by regulating PI3K/AKT signaling.