Inhibitory Effects of Soyeum Pharmacopuncture (SPP) on LPS-induced Inflammation Related Cytokine Expressions of RAW 264.7 cells
Aim : This study was done to investigate whether SPP has inhibitory effects on the activation of RAW 264.7 cells. Method : In tumor necrosis factor-a (TNF-a)/ interleukin-1b (IL-1b) and IL-6, the mRNA expression of molecular indicators related to inflammatory changes of the Reumatoid Arthritis (RA)...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2007-12-01
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| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2007.10.3.021 |
| Summary: | Aim : This study was done to investigate whether SPP has inhibitory effects on the activation of RAW 264.7 cells.
Method : In tumor necrosis factor-a (TNF-a)/ interleukin-1b (IL-1b) and IL-6, the mRNA expression of molecular indicators related to inflammatory changes of the Reumatoid Arthritis (RA) were examined using quantitative real-time PCR.
Results : The treatment of SPP significantly suppressed the expression of proinflammatory cytokines and chemokines such as TNF-a, IL-1b, IL-6 compared with the control. The expression of NOS-II was considerably reduced, which was accompanied by a reduction in the production of nitric oxide (NO). It also reduced the expression of TNF-αin serum of Balb/c mice compared with control group.
Conclusion : SPP is an effective herbal material for suppressing the inflammation related cytokines of RAW 264.7 cells. |
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| ISSN: | 2093-6966 2234-6856 |