Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease

Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease

Accumulating evidence suggests that inflammatory mediators secreted by activated resident or infiltrated innate immune cells have a significant impact on the pathogenesis of neurodegenerative diseases. This may imply that patients affected by a neurodegenerative disease may benefit from treatment wi...

Full description

Bibliographic Details
Main Authors: Bert A. ‘t Hart, Sjef Copray, Ingrid Philippens
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/298020
id doaj-0710226d09d64d2d839ab9801a00ccb3
record_format Article
spelling doaj-0710226d09d64d2d839ab9801a00ccb32020-11-24T22:44:12ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/298020298020Apocynin, a Low Molecular Oral Treatment for Neurodegenerative DiseaseBert A. ‘t Hart0Sjef Copray1Ingrid Philippens2Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The NetherlandsDepartment of Neuroscience, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The NetherlandsDepartment of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The NetherlandsAccumulating evidence suggests that inflammatory mediators secreted by activated resident or infiltrated innate immune cells have a significant impact on the pathogenesis of neurodegenerative diseases. This may imply that patients affected by a neurodegenerative disease may benefit from treatment with selective inhibitors of innate immune activity. Here we review the therapeutic potential of apocynin, an essentially nontoxic phenolic compound isolated from the medicinal plant Jatropha multifida. Apocynin is a selective inhibitor of the phagocyte NADPH oxidase Nox2 that can be applied orally and is remarkably effective at low dose.http://dx.doi.org/10.1155/2014/298020
collection DOAJ
language English
format Article
sources DOAJ
author Bert A. ‘t Hart
Sjef Copray
Ingrid Philippens
spellingShingle Bert A. ‘t Hart
Sjef Copray
Ingrid Philippens
Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
BioMed Research International
author_facet Bert A. ‘t Hart
Sjef Copray
Ingrid Philippens
author_sort Bert A. ‘t Hart
title Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
title_short Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
title_full Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
title_fullStr Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
title_full_unstemmed Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
title_sort apocynin, a low molecular oral treatment for neurodegenerative disease
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Accumulating evidence suggests that inflammatory mediators secreted by activated resident or infiltrated innate immune cells have a significant impact on the pathogenesis of neurodegenerative diseases. This may imply that patients affected by a neurodegenerative disease may benefit from treatment with selective inhibitors of innate immune activity. Here we review the therapeutic potential of apocynin, an essentially nontoxic phenolic compound isolated from the medicinal plant Jatropha multifida. Apocynin is a selective inhibitor of the phagocyte NADPH oxidase Nox2 that can be applied orally and is remarkably effective at low dose.
url http://dx.doi.org/10.1155/2014/298020
work_keys_str_mv AT bertathart apocyninalowmolecularoraltreatmentforneurodegenerativedisease
AT sjefcopray apocyninalowmolecularoraltreatmentforneurodegenerativedisease
AT ingridphilippens apocyninalowmolecularoraltreatmentforneurodegenerativedisease
_version_ 1725692300923764736

Similar Items