Common Features of Regulatory T Cell Specialization During Th1 Responses

Common Features of Regulatory T Cell Specialization During Th1 Responses

CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXC...

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Bibliographic Details
Main Authors: Katharina Littringer, Claudia Moresi, Nikolas Rakebrandt, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Florian Kirchner, Felix Rost, Christian W. Keller, Donal McHugh, Salomé LeibundGut-Landmann, Mark D. Robinson, Nicole Joller
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
Treg cells
CXCR3
T-bet
Th1
co-inhibitory receptors
CD85k
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01344/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01344/full

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