Effects of aged garlic extract on spatial memory and oxidative damage in the brain of amyloid-β induced rats

• Main Authors: Thanyaporn Wichai, Wanassanun Pannangrong, Jariya Umka Welbat, Amnard Chaichun, Kittisak Sripanidkulchai, Bungorn Sripanidkulchai
• Format: Article
• Language: English
• Published: Prince of Songkla University 2019-04-01
• Series: Songklanakarin Journal of Science and Technology (SJST)
• Subjects: aged garlic extract; hippocampus; Morris water maze; oxidative stress; spatial memory
• Online Access: https://rdo.psu.ac.th/sjstweb/journal/41-2/10.pdf
• ISSN: 0125-3395

This study investigated the effect of aged garlic extract (AGE) on spatial learning and memory ability using Morris water maze (MWM) test in amyloid-β (Aβ) induced-neurotoxicity rats. Pretreatment of AGE at oral doses of 125, 250 and 500 mg/kg for 8 weeks significantly prevented the learning and short-term memory impairment in Aβ-induced neurotoxicity rats. Histological analysis has shown that pretreatment of AGE reversed the neuron loss in the CA1 and CA2 regions of hippocampus of Aβ-induced neurotoxicity in a comparable effect of ascorbic acid. By DPPH and FRAP determination, AGE had high antioxidative activity. Pretreatment of AGE caused significant increases of superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, no significant change in catalase (CAT) activity, and a significant decrease of malondialdehyde (MDA) level of the Aβ-induced rat brain homogenate. The results suggest that AGE ameliorates the cognitive dysfunction in Aβ- induced neurotoxicity rats via its antioxidative effect.