Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners.
Date hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein...
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doaj-07072cc8084f45e7914c8956e76097bc2020-11-25T02:42:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4820910.1371/journal.pone.0048209Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners.Apurv GoelMarc R WilkinsDate hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein interaction networks to analyse the interactions of all the 1 or 2 interface hubs of Saccharomyces cerevisiae during the cell cycle. By integrating previously determined structural and gene expression data, and visually hiding the nodes (proteins) and their edges (interactions) during their troughs of expression, we predict when interactions of hubs and their partners are likely to exist. This revealed that 20 out of all 36 one- or two- interface hubs in the yeast interactome fell within two main groups. The first was dynamic hubs with static partners, which can be considered as 'competitive hubs'. Their interaction partners will compete for the interaction interface of the hub and the success of any interaction will be dictated by the kinetics of interaction (abundance and affinity) and subcellular localisation. The second was static hubs with dynamic partners, which we term 'non-competitive hubs'. Regulatory mechanisms are finely tuned to lessen the presence and/or effects of competition between the interaction partners of the hub. It is possible that these regulatory processes may also be used by the cell for the regulation of other, non-cell cycle processes.http://europepmc.org/articles/PMC3485199?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Apurv Goel Marc R Wilkins |
spellingShingle |
Apurv Goel Marc R Wilkins Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. PLoS ONE |
author_facet |
Apurv Goel Marc R Wilkins |
author_sort |
Apurv Goel |
title |
Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. |
title_short |
Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. |
title_full |
Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. |
title_fullStr |
Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. |
title_full_unstemmed |
Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. |
title_sort |
dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Date hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein interaction networks to analyse the interactions of all the 1 or 2 interface hubs of Saccharomyces cerevisiae during the cell cycle. By integrating previously determined structural and gene expression data, and visually hiding the nodes (proteins) and their edges (interactions) during their troughs of expression, we predict when interactions of hubs and their partners are likely to exist. This revealed that 20 out of all 36 one- or two- interface hubs in the yeast interactome fell within two main groups. The first was dynamic hubs with static partners, which can be considered as 'competitive hubs'. Their interaction partners will compete for the interaction interface of the hub and the success of any interaction will be dictated by the kinetics of interaction (abundance and affinity) and subcellular localisation. The second was static hubs with dynamic partners, which we term 'non-competitive hubs'. Regulatory mechanisms are finely tuned to lessen the presence and/or effects of competition between the interaction partners of the hub. It is possible that these regulatory processes may also be used by the cell for the regulation of other, non-cell cycle processes. |
url |
http://europepmc.org/articles/PMC3485199?pdf=render |
work_keys_str_mv |
AT apurvgoel dynamichubsshowcompetitiveandstatichubsnoncompetitiveregulationoftheirinteractionpartners AT marcrwilkins dynamichubsshowcompetitiveandstatichubsnoncompetitiveregulationoftheirinteractionpartners |
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