Homeostasis of protein and mRNA concentrations in growing cells
For various organisms, mRNA and protein copy numbers scale with cell volume. Here, the authors show that this result emerges naturally when ribosomes and RNAPs limit expression. Furthermore, the authors show that within their model this result breaks down for a sufficiently high volume/DNA ratio.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06714-z |