Eco-friendly and Convenient Synthesis of Biologically Active Polysubstituted Dihydro-2-Oxypyrroles Using Manganese (II) Nitrate Tetrahydrate at Ambient Temperatures
A convenient, expedient and efficient method for the synthesis of polysubstituted dihydro-2-oxypyrroles is described via the one-pot four-condensation of dialkyl acetylenedicarboxylate, formaldehyde, and amines (aromatic and aliphatic) at ambient temperature in the presence of Manganese (II) Nitrate...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2019-03-01
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| Series: | Makara Journal of Science |
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| Online Access: | http://journal.ui.ac.id/index.php/science/article/view/9687/67546399 |
| Summary: | A convenient, expedient and efficient method for the synthesis of polysubstituted dihydro-2-oxypyrroles is described via the one-pot four-condensation of dialkyl acetylenedicarboxylate, formaldehyde, and amines (aromatic and aliphatic) at ambient temperature in the presence of Manganese (II) Nitrate Tetrahydrate (Mn(NO3)2.4H2O) as a cost effective and inexpensive catalyst. The present methodology provides a simple and eco-safe procedure for the synthesis of polysubstituted dihydro-2-oxypyrroles with some additional advantages, such as good to high yields, short reaction times, avoidance of hazardous or toxic catalysts, simplicity of operating and work-up procedures with no necessity for chromatographic purification steps. |
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| ISSN: | 2339-1995 2356-0851 |