Involvement of Voltage-Gated Sodium Channel NaV1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons

Involvement of Voltage-Gated Sodium Channel NaV1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons

This study was conducted to determine whether Nav1.8 contributes to the release and/or synthesis of substance P (SP) in adult mice dorsal root ganglion (DRG) neurons. The SP released from cultured DRG neurons of Nav1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than th...

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Bibliographic Details
Main Authors: He-Bin Tang, Eri Shiba, Yu-Sang Li, Norimitsu Morioka, Tai-Xing Zheng, Nobukuni Ogata, Yoshihiro Nakata
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319313544

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