Effect of Zingiber Officinale Sucus on contraction of isolated duodenum in rabbits①
Objective: Observation of ginger (Zingiber Officinale Sucus, ZOS) effect on rabbit isolated duodenum and to explore the correlation mechanism with M and H1 receptor. To investigate the effects of ZOS on isolated duodenum of rabbits treated with acetylcholine, histamine, atropine and chlorpheniram...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2020-01-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/202001/3.pdf |
| Summary: | Objective: Observation of ginger (Zingiber Officinale Sucus, ZOS) effect on rabbit isolated
duodenum and to explore the correlation mechanism with M and H1 receptor. To investigate
the effects of ZOS on isolated duodenum of rabbits treated with acetylcholine, histamine,
atropine and chlorpheniramine respectively. Methods: The optimal concentration of ZOS
was 1% and the above drugs were applied to the isolated duodenal segments respectively. The
contractile force was recorded by BL-420E biological signal acquisition system. Results: The
results showed that ZOS significantly inhibited the contraction of isolated rabbit duodenal
smooth muscle in a positive concentration-dependent manner. The mechanism of inhibiting
contraction had little correlation with M and H1 receptors. Conclusion: It could inhibit the
efficacy of acetylcholine and histamine, and was a synergist for atropine and chlorpheniramine.
This study provided a basis for the use of ginger in daily life and the development of combined
medication. |
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| ISSN: | 1007-1237 1007-1237 |