Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]

Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]

Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult s...

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Main Authors: Daniel A. Berg, Allison M. Bond, Guo-li Ming, Hongjun Song
Format: Article
Language:English
Published: F1000 Research Ltd 2018-03-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-277/v1
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spelling doaj-06f1a21bede142808ecc20e8bb1f8c132020-11-25T03:15:26ZengF1000 Research LtdF1000Research2046-14022018-03-01710.12688/f1000research.12684.113735Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]Daniel A. Berg0Allison M. Bond1Guo-li Ming2Hongjun Song3Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USADepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USADepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USADepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USAAdult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.https://f1000research.com/articles/7-277/v1
collection DOAJ
language English
format Article
sources DOAJ
author Daniel A. Berg
Allison M. Bond
Guo-li Ming
Hongjun Song
spellingShingle Daniel A. Berg
Allison M. Bond
Guo-li Ming
Hongjun Song
Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
F1000Research
author_facet Daniel A. Berg
Allison M. Bond
Guo-li Ming
Hongjun Song
author_sort Daniel A. Berg
title Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
title_short Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
title_full Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
title_fullStr Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
title_full_unstemmed Radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
title_sort radial glial cells in the adult dentate gyrus: what are they and where do they come from? [version 1; referees: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2018-03-01
description Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.
url https://f1000research.com/articles/7-277/v1
work_keys_str_mv AT danielaberg radialglialcellsintheadultdentategyruswhataretheyandwheredotheycomefromversion1referees2approved
AT allisonmbond radialglialcellsintheadultdentategyruswhataretheyandwheredotheycomefromversion1referees2approved
AT guoliming radialglialcellsintheadultdentategyruswhataretheyandwheredotheycomefromversion1referees2approved
AT hongjunsong radialglialcellsintheadultdentategyruswhataretheyandwheredotheycomefromversion1referees2approved
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