Lysophosphatidic Acid Up-regulates MT1-MMP Expression through a Gi –dependent Pathway in Human Umbilical Vein Endothelial Cells

Lysophosphatidic Acid Up-regulates MT1-MMP Expression through a Gi –dependent Pathway in Human Umbilical Vein Endothelial Cells

Lysophosphatidic acid (LPA) is a low molecular weight lysophospholipid (LPL). Through binding to its specific G protein-coupled receptor family, LPA regulates various cellular functions, including proliferation, migration, invasion, and differentiation. Matrix-metalloproteinases (MMPs) are zinc-depe...

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Bibliographic Details
Main Authors: Po-Wei Lin, Yuan-Li Huang, Shee-Uan Chen, Hsinyu Lee
Format: Article
Language:English
Published: National Taiwan University 2009-11-01
Series:Taiwania
Subjects:
LPA
MT1-MMP
MMP-2
HUVECs
ECM
Online Access:http://tai2.ntu.edu.tw/taiwania/abstract.php?type=abstract&id=935

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