Paget's disease of the nipple in males: two case reports and literature review

Abstract. Male breast cancer accounts for less than 0.5% of all breast cancer, and Paget disease of the breast in males is extremely rare. Here, we report 2 cases of Paget disease of the nipple areola complex with invasive ductal carcinoma as typical examples of male PDB. Case 1 was a 64-year-old ma...

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Bibliographic Details
Main Authors: Jie Wang, Jiaqi Liu, Zeyu Xing, Xiangzhi Meng, Menglu Zhang, Xin Wang, Xiang Wang
Format: Article
Language:English
Published: Wolters Kluwer Health 2018-09-01
Series:Journal of Bio-X Research
Online Access:http://journals.lww.com/10.1097/JBR.0000000000000012
Description
Summary:Abstract. Male breast cancer accounts for less than 0.5% of all breast cancer, and Paget disease of the breast in males is extremely rare. Here, we report 2 cases of Paget disease of the nipple areola complex with invasive ductal carcinoma as typical examples of male PDB. Case 1 was a 64-year-old man with an altered appearance of the left nipple, itching and redness, without a palpable breast mass at first. Case 2 was a 55-year-old man with a palpable mass in the left breast and histologically confirmed Paget disease of the nipple with invasive ductal carcinoma. Both patients underwent modified radical mastectomy but with different adjuvant therapies and remained well during follow-up with no recurrence. Furthermore, we reviewed all the sporadic cases of male PDB from the literature. This may help contribute to the development of diagnostic strategies and appropriate interventions for male Paget disease of the breast.
ISSN:2096-5672
2577-3585