Senescence Induces Dysfunctions in Endothelial Progenitor Cells and Osteoblasts by Interfering Translational Machinery and Bioenergetic Homeostasis

Senescence Induces Dysfunctions in Endothelial Progenitor Cells and Osteoblasts by Interfering Translational Machinery and Bioenergetic Homeostasis

Age-related bone diseases are partly caused by impaired bone integrity, which are closely related to osteoblasts’ activity and angiogenesis. Endothelial progenitor cells (EPCs) are the initiators of angiogenesis and found to have senescent-induced dysfunctions. The aim of this study is to investigat...

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Bibliographic Details
Main Authors: Guo-Shou Wang, Yung-Shuen Shen, Wen-Yi Chou, Chih-Hsin Tang, Hung-I Yeh, Li-Yu Wang, Juei-Yu Yen, Te-Yang Huang, Shih-Chia Liu, Chen-Yu Yang, Ting-Yi Lin, Chi Chen, Shih-Wei Wang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial progenitor cell
osteoblast
senescence
Akt/mTOR/p70S6K
ATP synthesis
Online Access:http://www.mdpi.com/1422-0067/19/7/1997

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