Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease

Introduction. The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn’s disease, where there is no absolute indication of surgery. Methods. Observational study involving patients with isolated ileocecal Crohn’s disease who underwent...

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Main Authors: Mirzafaraz Saeed, Hari Hullur, Amro Salem, Abbas Ali, Yousif Sahib, Mobeen Ashfaq
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Surgery Research and Practice
Online Access:http://dx.doi.org/10.1155/2017/4396573
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spelling doaj-06c1e95ccce64a85b8534121fd56e0102020-11-24T23:45:15ZengHindawi LimitedSurgery Research and Practice2356-77592356-61242017-01-01201710.1155/2017/43965734396573Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s DiseaseMirzafaraz Saeed0Hari Hullur1Amro Salem2Abbas Ali3Yousif Sahib4Mobeen Ashfaq5Department of Surgery, King Hamad University Hospital, Busaiteen, BahrainKing Hamad University Hospital, Busaiteen, BahrainDepartment of Surgery, King Hamad University Hospital, Busaiteen, BahrainKing Hamad University Hospital, Busaiteen, BahrainKing Hamad University Hospital, Busaiteen, BahrainKing Hamad University Hospital, Busaiteen, BahrainIntroduction. The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn’s disease, where there is no absolute indication of surgery. Methods. Observational study involving patients with isolated ileocecal Crohn’s disease who underwent early surgical resection (within one year of the presentation of the hospital). A complete blood count, ESR, and CRP were done and compared between the preoperative value, 1st postoperative visit (3-4 weeks), and last follow-up visit. Statistical analysis was done using Analysis of Variance (ANOVA) to compare the different figures. Results. There was a statistically significant increase in the hemoglobin levels between preoperative, postoperative, and long-term follow-up and a significant decrease in leukocyte count between the pre- and postoperative values (F=19.8, p<0.001 and F=8.9, p=0.002, resp.). Similarly, the ESR and CRP values were decreased significantly at long-term follow-up (F=8.5, p=0.019 and F=8.3, p=0.013, resp.). Conclusion. Early surgical resection in isolated ileocaecal Crohn’s disease achieved significant biochemical improvements. These successful results in this small number of patients indicate that early surgical intervention may provide better outcomes. These initial results encourage larger and comparative studies of long-term results versus long-term use of biological agents.http://dx.doi.org/10.1155/2017/4396573
collection DOAJ
language English
format Article
sources DOAJ
author Mirzafaraz Saeed
Hari Hullur
Amro Salem
Abbas Ali
Yousif Sahib
Mobeen Ashfaq
spellingShingle Mirzafaraz Saeed
Hari Hullur
Amro Salem
Abbas Ali
Yousif Sahib
Mobeen Ashfaq
Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease
Surgery Research and Practice
author_facet Mirzafaraz Saeed
Hari Hullur
Amro Salem
Abbas Ali
Yousif Sahib
Mobeen Ashfaq
author_sort Mirzafaraz Saeed
title Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease
title_short Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease
title_full Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease
title_fullStr Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease
title_full_unstemmed Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease
title_sort improved biochemical parameters in patients who undergo early resection in isolated ileocaecal crohn’s disease
publisher Hindawi Limited
series Surgery Research and Practice
issn 2356-7759
2356-6124
publishDate 2017-01-01
description Introduction. The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn’s disease, where there is no absolute indication of surgery. Methods. Observational study involving patients with isolated ileocecal Crohn’s disease who underwent early surgical resection (within one year of the presentation of the hospital). A complete blood count, ESR, and CRP were done and compared between the preoperative value, 1st postoperative visit (3-4 weeks), and last follow-up visit. Statistical analysis was done using Analysis of Variance (ANOVA) to compare the different figures. Results. There was a statistically significant increase in the hemoglobin levels between preoperative, postoperative, and long-term follow-up and a significant decrease in leukocyte count between the pre- and postoperative values (F=19.8, p<0.001 and F=8.9, p=0.002, resp.). Similarly, the ESR and CRP values were decreased significantly at long-term follow-up (F=8.5, p=0.019 and F=8.3, p=0.013, resp.). Conclusion. Early surgical resection in isolated ileocaecal Crohn’s disease achieved significant biochemical improvements. These successful results in this small number of patients indicate that early surgical intervention may provide better outcomes. These initial results encourage larger and comparative studies of long-term results versus long-term use of biological agents.
url http://dx.doi.org/10.1155/2017/4396573
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