Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

Zinc Finger Nucleases (ZFNs) made by Context-Dependent Assembly (CoDA) and Transcription Activator-Like Effector Nucleases (TALENs) provide robust and user-friendly technologies for efficiently inactivating genes in zebrafish. These designer nucleases bind to and cleave DNA at particular target site...

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Bibliographic Details
Main Authors: Finola E Moore, Deepak Reyon, Jeffry D Sander, Sarah A Martinez, Jessica S Blackburn, Cyd Khayter, Cherie L Ramirez, J Keith Joung, David M Langenau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360007?pdf=render

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