Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

Subtype-specific neurons obtained from adult humans will be critical to modeling neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Here, we show that adult human skin fibroblasts can be directly and efficiently converted into highly pure motor neurons without passing through a...

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Bibliographic Details
Main Authors: Meng-Lu Liu, Tong Zang, Chun-Li Zhang
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
ALS disease
direct reprogramming
motor neuron
NEUROG2
small molecules
kenpaullone
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471501431X

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