Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium

Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium

Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure. In this study, gastric-resistant isoniazid pellets...

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Bibliographic Details
Main Authors: Fátima Duarte Freire, Manuela Bernardo Câmara, Monique Gomes Dantas, Cícero Flávio Soares Aragão, Túlio Flávio Accioly de Lima e Moura, Fernanda Nervo Raffin
Format: Article
Language:English
Published: Universidade de São Paulo 2014-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Rifampicina
Isoniazidas gastrorresistentes/péletes
Péletes/revestimento entérico
Acrycoat L 100(r)/uso/revestimento entérico
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400749&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400749&lng=en&tlng=en

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