Nerve Growth Factor Compromise in Down Syndrome

Nerve Growth Factor Compromise in Down Syndrome

The basal forebrain cholinergic system relies on trophic support by nerve growth factor (NGF) to maintain its phenotype and function. In Alzheimer’s disease (AD), basal forebrain cholinergic neurons (BFCNs) undergo progressive atrophy, suggesting a deficit in NGF trophic support. Within the central...

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Bibliographic Details
Main Authors: Sonia Do Carmo, Benjamin Kannel, A. Claudio Cuello
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s
Down syndrome
nerve growth factor
metabolic pathway
basal forebrain cholinergic neuron
cholinergic dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.719507/full

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