miR-499-5p Attenuates Mitochondrial Fission and Cell Apoptosis via p21 in Doxorubicin Cardiotoxicity

miR-499-5p Attenuates Mitochondrial Fission and Cell Apoptosis via p21 in Doxorubicin Cardiotoxicity

Doxorubicin (DOX) is a broad-spectrum anti-tumor drug, but its cardiotoxicity limits its clinical application. A better understanding of the molecular mechanisms underlying DOX cardiotoxicity will benefit clinical practice and remedy heart failure. Our present study observed that DOX caused cardiomy...

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Bibliographic Details
Main Authors: Qinggong Wan, Tao Xu, Wei Ding, Xuejuan Zhang, Xiaoyu Ji, Tao Yu, Wanpeng Yu, Zhijuan Lin, Jianxun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Genetics
Subjects:
doxorubicin
miR-499-5p
p21
cardiotoxicity
mitochondrial
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00734/full

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