Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells

Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells

Abstract Background Liver cancer stem cells (LCSCs) are a small subset of cells characterized by unlimited self-renewal, cell differentiation, and uncontrollable cellular growth. LCSCs are also resistant to conventional therapies and are thus believed to be held responsible for causing treatment fai...

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Bibliographic Details
Main Authors: Dong-Mei Wu, Zi-Hui Zheng, Ying-Bo Zhang, Shao-Hua Fan, Zi-Feng Zhang, Yong-Jian Wang, Yuan-Lin Zheng, Jun Lu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
LncRNA DLX6-AS1
CADM1
STAT3 signaling pathway
Hepatocellular carcinoma
Liver cancer stem cell
Online Access:http://link.springer.com/article/10.1186/s13046-019-1239-3

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