The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope.

The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope.

OBJECTIVES:This study was designed to identify common HIV-1 mutation complexes affecting the slope of inhibition curve, and to propose a new parameter incorporating both the IC50 and the slope to evaluate phenotypic resistance. METHODS:Utilizing site-directed mutagenesis, we constructed 22 HIV-1 com...

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Bibliographic Details
Main Authors: Shuai Chang, Daomin Zhuang, Wei Guo, Lin Li, Wenfu Zhang, Siyang Liu, Hanping Li, Yongjian Liu, Zuoyi Bao, Jingwan Han, Hongbin Song, Jingyun Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4773073?pdf=render

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