Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop

Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop

Human immunodeficiency virus-1 (HIV-1) replication and gene expression entails specific interaction of the viral protein Tat with its transactivation responsive element (TAR), to form a highly stable stem-bulge-loop structure. Previously, we described triphenylphosphonium (TPP) cation-based vectors...

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Bibliographic Details
Main Authors: Gregory Upert, Audrey Di Giorgio, Alok Upadhyay, Dinesh Manvar, Nootan Pandey, Virendra N. Pandey, Nadia Patino
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.1155/2012/591025

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