Diagnostic value of blood urea and bilirubin levels determination in patients with gastroduodenal zone diseases

• Main Authors: I. B. Zhakun, O. O. Sorokopud, L. M. Strilchuk, Z. M. Kit, M. O. Kondratyuk
• Format: Article
• Language: English
• Published: Zaporozhye State Medical University 2017-12-01
• Series: Zaporožskij Medicinskij Žurnal
• Subjects: urea; bilirubin; Helicobacter pylori (HP); gastroduodenal diseases; diseases eradication; biliary tract diseases; pneumonia
• Online Access: http://zmj.zsmu.edu.ua/article/view/114717/113461
• ISSN: 2306-4145; 2310-1210

The study of relationships of urea and bilirubin blood levels in patients with Helicobacter pylori associated gastroduodenal pathology (HP-aGDP) has the considerable relevance for clinicians, since these indicators represent the status and function of the gastroduodenal zone. The aim of this study was to estimate changes of bilirubin and urea blood levels in patients with HP-aGDP before and after treatment. Materials and methods. Our study has included 59 patients of the main group with different HP-aGDP and 40 patients of the control group with community-acquired pneumonia (CAP). Results. In patients with HP-aGDP the doubly severe reduction of urea concentration was observed in significantly greater number of patients, while half of the patients in the controls had an increase of its level by 10.4 %. The bilirubin concentration decrease was more pronounced (37.1 % vs. 3.5 %) and significant (p < 0.05) in patients with HP-aGDP. Its rate depended on the dynamics of urea exactly in patients with HP-aGDP and it was more pronounced in case of urea reduction (p < 0.05). Thus, the revealed association of bilirubin and urea levels changes, namely their decrease owing to the treatment, was inherent only to patients with HP-aGDP unlike to the patients with CAD. We also determined the involvement of lipid, carbohydrate and protein metabolism, electrolytes, composition of blood in the processes of local and systemic inflammation caused by HP and its relationship with adaptive reactions, which generally depended on other individual characteristics of patients in the study group (age, duration of disease, ulcer size, etc.). Conclusions. The monitoring of urea and bilirubin blood levels in patients especially with HP-aGDP during the eradication has a specific diagnostic and prognostic value. The bilirubin level in such cases reflects the severity of cholestasis, inflammatory lesions of the duodenal mucosa, comorbid hepatobiliary disease, while the urea level reduction may be an additional criterion of efficacy of HP eradication.