Amifostine Analog, DRDE-30, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

Amifostine Analog, DRDE-30, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from...

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Bibliographic Details
Main Authors: Aastha Arora, Vikas Bhuria, Puja P. Hazari, Uma Pathak, Sweta Mathur, Bal G. Roy, Rajat Sandhir, Ravi Soni, Bilikere S. Dwarakanath, Anant N. Bhatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
lung inflammation
lung fibrosis
bleomycin
DRDE-30
Amifostine
micro-computed tomography
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00394/full

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